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5 Facts you should know about
PLCG2-associated Antibody Deficiency and Immune Dysregulation (PLAID)
1
An allergic response to cold, called cold urticaria, is the most distinct symptom
2
The allergic response to cold likely results from abnormal activation of immune cells at low temperatures
3
Additionally, some individuals with PLAID can develop a burn-like rash at birth in areas most likely to be exposed to cold temperatures, such as the nose
4
Also typical are recurrent bacterial infections and an increased likelihood of developing autoimmune disorders
5
Another common symptom is a burning sensation in the throat when eating cold food
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